WebThe process of cell division, whether normal or cancerous cells, is through the cell cycle. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division). The ability of chemotherapy to kill cancer cells depends on its ability to … ICE Non-Hodgkin's Lymphoma ICE-V Small Cell Lung Cancer IFL Colorectal Cancer … Eye Problems and Cancer Treatment: Includes: Cataracts, conjunctivitis (pink … Have questions about chemotherapy? Call the Cancer Answer Line at Cleveland … WebCytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G 1 phase to the S-phase. Although the mechanism of action is not completely understood, it ...

DRUG NAME: Cytarabine - BC Cancer

WebCytarabine is a cell cycle phase-specific antineoplastic agent, affecting cells only during the S-phase of cell division. Cytarabine acts primarily through inhibition of DNA … iro clearance

Cytarabine C9H13N3O5 - PubChem

WebIts mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. WebJul 5, 2024 · Cytarabine induces cell cycle arrest and activates Chk1. U937 cells were incubated with AICAr (AIC) (0.2 mM), brequinar (Bq) (0.5 µM) and AraC (10, 100, 1000 nM). ( A) Representative... http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cytarabine_monograph_1May2014.pdf iro cream tweed jacket