Human foamy virus (HFV) is a retrovirus and specifically belongs to the genus Spumavirus. The spumaviruses are complex and significantly different from the other six genera of retroviruses in several ways. The foamy viruses derive their name from the characteristic ‘foamy’ appearance of the cytopathic effect … See more The first description of foamy virus (FV) was in 1954. It was found as a contaminant in primary monkey kidney cultures. The first isolate of the “foamy viral agent” was in 1955. Not too long after this, it was isolated … See more If, in fact, HFV is not pathogenic in humans and is a retrovirus, it is an ideal vector for gene therapy. Another important feature of the virus is that the Gag, Pol, and Env proteins are synthesized independently; this is important because it means that each … See more Most of the differences between the spumaviruses and the other retroviruses come from the life cycle. Some of the main differences are that … See more Persistence in the absence of disease, but in the presence of antibodies is a defining characteristic of FV infection. HFV has been isolated from patients with various neoplastic and … See more • Human+foamy+virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more WebJul 1, 2016 · We describe a self-inactivating foamy virus vector (FVV), incorporating the simian macaque foamy virus envelope and using physiological promoters, which …
The crystal structure of a simian Foamy Virus receptor binding …
WebJun 5, 2014 · Intravenous injection of a foamy virus carrying a corrective gene facilitates immune cell development in a canine model of SCID-X1. Integration site analysis … WebMar 18, 2024 · The application of gene therapy for CLAD I, using hematopoietic stem cells transduced with foamy viral vector harboring the CD18 gene construct, was successful, as documented by a long-term (up to 7-year) follow-up of four treated dogs (Bauer et al. 2013). Muscular dystrophy. external fish breeder box
Foamy virus for efficient gene transfer in regeneration studies
WebJan 20, 2006 · Foamy viruses (FVs) or spumaviruses are retroviruses that have been developed as vectors, but their integration patterns have not been described. We have performed a large-scale analysis of FV integration sites in unselected human fibroblasts ( n = 1,008) and human CD34 + hematopoietic cells ( n = 1,821) by using a bacterial shuttle … WebRetroviral vectors are significant for basic biological investigations such as studies of cell lineage, mechanisms of carcinogenesis, and developmental and tissue-specific … WebJan 20, 2006 · Abstract. Foamy viruses (FVs) or spumaviruses are retroviruses that have been developed as vectors, but their integration patterns have not been described. We … external fish anatomy diagram