WebApr 13, 2024 · Consistent with these observations on CLA-1L size and position at the synapses, we uncover genetic interactions between CLA-1L and periactive zone proteins EHS-1/EPS15 or ITSN-1/intersectin 1, which have been suggested as linkers between active zone exocytosis and periactive zone endocytosis [61,62,72–79]. WebApr 10, 2024 · Updated: Apr 10, 2024 / 04:10 PM CDT. FORT DODGE, IOWA- The Iowa Department of Transportation is considering using a new type of intersection across the state. It’s called a Reduced Conflict Intersection. The first one was installed on Highway 20 just east of Fort Dodge after the owners of Marker 126 Travel Center requested a safer ...
Intersectin 1: a versatile actor in the synaptic vesicle cycle
WebAug 15, 2016 · This recruitment polarizes the viral protein A36 beneath the virus, enhancing actin polymerization and the spread of infection. We now demonstrate that three NPF motifs in the C-terminus of A36 recruit AP-2 and clathrin by interacting directly with the Epsin15 homology domains of Eps15 and intersectin-1. WebObjective: Intersectin 2 (ITSN2) is reported to cause hereditary nephrotic syndrome, but the number of cases remains quite small. We observed a case of progressive renal dysfunction and family history for end-stage kidney disease with a known single heterozygous ITSN2 variant. This study aimed to reveal the novel pathological significance of altered ITSN2 … intruder within 1981
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WebOct 17, 2006 · Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones ( By similarity ). WebDecreasing intersectin 1 expression prevented the internalization of ROMK which then increased K + transport. An earlier study by the same group identified miR-802 similarly regulated by altered K + diet. In this case the target protein was caveolin-1 (Lin, Yue, Pan, Sun, & Wang, 2011). Web5 hours ago · WARREN, Mich. – Two drivers and two children were injured when a Jeep and a pickup truck collided at a major intersection in Warren. The crash happened at 7:28 … new pm in italy