Klf5 phosphorylation

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August undefined, 2024

WebDownload scientific diagram Role of AMPK/mTOR pathway in morusin-induced autophagy in non-small cell lung cancer cells. Cells were treated with morusin (20 μM) at various time periods. (A) The ... WebDec 6, 2024 · Furthermore, we detected the levels of klf5 phosphorylation, suggesting klf5 phosphorylation level in HFD group was lower than HFD+RSV group. In parallel, in HEK293 cells, we also observed that HG (25 mmol/L) enhanced the interaction of klf5 with c-Myc and klf5 dephosphorylation, which were reversed by treatment with inhibitor LY294002 and RSV.

Single‐Cell RNA‐Sequencing Analysis Reveals Divergent …

WebDec 10, 2013 · Phosphorylation of KLF5 on serine 406 also enhances interaction with unliganded RARα, which binds to the first zinc finger of the KLF5 DBD, to activate downstream target genes 90, 93. RAR agonists are thought to act via two mechanisms to disrupt the interaction between KLF5 and RARα and subsequently inhibit VSMC … WebApr 14, 2024 · Enhancer RNAs (eRNAs) are non-coding RNAs (ncRNAs) transcribed in enhancer regions. They play an important role in transcriptional regulation, mainly during cellular differentiation. eRNAs are tightly tissue- and cell-type specific and are induced by specific stimuli, activating promoters of target genes in turn. eRNAs usually have a very … haenim toys korea

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WebNov 16, 2012 · Abstract 2313. Krüppel-like factor 5 (KLF5) is a member of a highly conserved group of transcription factors (the KLF family) that have regulatory roles in … WebJul 2, 2007 · KLF5 loss specifically resulted in reduced Bad phosphorylation at both ser112 and ser136 residues. Densitometric analysis confirmed that reduced Bad phosphorylation was significant across... WebVarious KLFs, including KLF5, are involved in cancer-related processes, such as epithelial-mesenchymal transition (EMT), invasion, and metastasis (3-6). In addition, studies show … haenim toy

Down-regulation of the klf5-c-Myc interaction due to klf5 ... - PLOS

688 - Gene ResultKLF5 KLF transcription factor 5 [ (human)]

WebKLF5 is a member of the Kruppel-like factor subfamily of zinc finger proteins. It contains three C2H2-type zinc fingers at the carboxyl-terminus that preferentially bind to cis-DNA … WebTriple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of pinko stick luvWeb目的探讨锌指转录因子Krüppel样因子5(Krüppel-like factor 5,KLF5)在高糖诱导的血管平滑肌细胞(vascular smooth muscle cells,VSMCs)炎症中的作用及机制.方法体外培养VSMCs,实时定量反转录聚合酶链反应(quantitative real-time polymerase chain reaction,qRT-PCR)、蛋白 … haenen joeri

"WebFeb 1, 2024 · Resveratrol induced KLF5 phosphorylation in renal HEK293 cells and prevented association of KLF5 with c-Myc. 25 Moreover, KLF5 phosphorylation could modulate its activation status as KLF5-Ser153 phosphorylation by protein kinase C at the CREB binding protein (CBP) interaction site promoted its transactivation function in … " - Klf5 phosphorylation

Klf5 phosphorylation

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WebDec 1, 2010 · Klf5 –/– embryos showed no expression of Eomes (C) or Krt8 (D). (E) Normal FGF-RTK-MAP kinase signaling in Klf5 –/– embryos. Phosphorylation (P) of ERK (p44/42 MAPK, also known as Erk1/2 and Mapk3/1) was at similar levels in control and mutant embryos. No background staining was detected in the absence of pERK antibodies. Web6.1 Phosphorylation. KLF5 has been shown to be phosphorylated by protein kinase C (PKC) at S153, which upregulates its transactivation activities by enhancing the interaction …

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WebMar 16, 2009 · To understand whether the change in KLF5 phosphorylation is responsible for Am80-induced suppression of interaction between KLF5 and RARα, we detected the levels of phospho-KLF5 in VSMCs treated with Am80. As shown in Fig. 3 A, Am80 stimulation rapidly induced dephosphorylation of KLF5 within 30 min. KLF5 … WebKrüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, …

WebApr 14, 2015 · Krüppel-like factor (KLF) 5, which initiates vascular smooth muscle cell (VSMC) proliferation, also participates in Angiotensin (Ang) II-induced vascular remodeling. The protective effect of rosiglitazone on vascular remodeling may be due to their impact on VSMC proliferation. However, the underlying mechanisms involved remain unclear. This … WebMay 10, 2024 · PRMT5 and KLF5 protein levels were positively correlated in clinical BLBCs. Taken together, PRMT5 methylates KLF5 to prevent its phosphorylation, ubiquitination, and degradation, and thus...

WebFeb 1, 2024 · KLF5 inhibition holds therapeutic potential for cardiovascular diseases. Abstract Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various pathways that pertain to development, metabolism and other cellular mechanisms. KLF5 was first cloned in 1993 and by 1999, it was reported as the intestinal-enriched KLF.

WebDec 28, 2009 · KLF5 is a downstream signal of the ERK 1/2 and p38 MAPK pathways, and activates the transcription of cyclin D1 gene via functional interaction with c-Jun in Ang II-induced VSMC proliferation. Keywords: Krüppel-like factor 5, cyclin D1, angiotensin II, proliferation, vascular smooth muscle cells Go to: Introduction

WebJun 16, 2024 · Herein, we analyzed KLF5 expression in TCGA and GEO database, as well as prostate cancer tissue microarray, and found that KLF5 expression significantly decreased in prostate cancer... haenel s20 air pistolWebApr 11, 2024 · SPI1, HIF1A, STAT1, KLF5, RUNX1, MBD1, SP1, and WT1 may be involved in the regulatory mechanisms of DN development. Our study may provide a potential biomarker or therapeutic locus for the study of DN. ... (Zhang et al., 2024c), STAT1 phosphorylation inhibited the M1 phenotypic transformation of macrophages and suppressed DN … haenen lucWebOct 11, 2024 · KLF5/BTEB2 is an essential transcription factor that causes not only smooth muscle phenotypic modulation but also cardiac hypertrophy and fibrosis; KLF5 has a role … pinkotanWebKrüppel-like factor 5 (KLF5) is an oncogenic factor that is highly expressed in basal-like breast cancer (BLBC) and promotes cell proliferation, survival, migration, stemness, and … haener sanitärWebMay 10, 2024 · PRMT5-induced KLF5R57me2 antagonizes GSK3β-mediated KLF5 phosphorylation and subsequently Fbw7-mediated KLF5 ubiquitination and coupled degradation. Functionally, PRMT5 promotes breast cancer ... pin kosuvamWebHDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. Abnormal … haen jotainWebNov 15, 2016 · Phosphorylation of KLF5 by PKC enhances the transcriptional activities of KLF5 by promoting its interaction with CREB binding protein . In addition, E3 ubiquitin ligase FBW7, a tumor suppressor, interacts with KLF5 for ubiquitination and degradation [11,12]. Despite understanding of KLF5’s role and its activity regulation in cardiovascular ... pinko tailleur